Brile Chung, M.S., Ph.D.
Immunolgy, Cell biology, Immuno-Oncology, Stem Cell Biology Specialty
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OUR VISION
Profile
PROFESSIONAL EDUCATION
Fellowship: Stanford University Division of Stem Cell Transplantation (2009)
Ph.D., University of Southern California (2005)
M.S., California State University, Los Angeles (2001)
B.S., University of California, San Diego (1994)
HONORS & AWARDS
Ernest McCulloch and James Till Award for the best science article in Biology of Blood and Marrow Transplantation by a new investigator, American Society for Blood and Marrow Transplantation, (ASBMT) Annual Meeting, San Diego, CA, 2012.
Invention: U.S. Provisional Patent: IL-7 receptor blockade to suppress immunity, CHLA Ref: 03-06; Ref. No: 9022.44PR, 2006.
Children’s Hospital Los Angeles Research Institute Poster Award, 2005
The American Society of Hematology Travel Award, 2003
Graduate Honorary Award (California State University of Los Angeles), 2001
Children’s Hospital Los Angeles Research Institute Poster Award, 1999
The American Society of Hematology Travel Award, 1999
The American Society of Hematology Travel Award, 1998
APPOINTMENTS
Assistant research professor, Department of Immuno-Oncology at City of Hope (2013 – 2017)
Staff Scientist, Department of Immuno-Oncology at City of Hope (2012 – 2013)
Junior Faculty, Department of Pathology and Laboratory Medicine, Broad Stem Cell Research Center, UCLA, David Geffen School of Medicine, UCLA (2011 – 2012)
PROFESSIONAL ACTIVITIES
Consulting activities: Scientific Consultant and Reviewer (for hematopoietic and mesenchymal stem cells), BioLegends, 2010 - Present
F1000 Associate Faculty Member/Post-publication peer review (since 10 November 2010).
Assigned to review 5 to 10 post-publication peer review, 2010 - 2012
Professional and scholarly associations: Membership in American Society for Blood and Marrow Transplantation
Teaching: Cal State University of Los Angeles: Immunology, 2000 and 2017
EDITORIAL SERVICES TO SCHOLARLY PUBLICATIONS
Stem Cells (May 2009-Present)
Human Gene Therapy (August 2011)
Journal of cardiovascular translational research (Oct 2010)
RESEARCH PAPERS (Scientific Peer-Reviewed)
Chung B, Barbara-Burnham L, Barsky L, Weinberg K. Radiosensitivity of thymic interleukin-7
production and thymopoiesis after bone marrow transplant. Blood. 2001. 98:1601-06.
Min D, Taylor PA, Panoskaltsis A, Chung B, Danilenko DM, Farrell C, Lacey DL, Blazar BR, Weinberg KI. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood. 2002;99:4592-4600.
Chung B, Dudl E, Min D, Barsky L, Smilely N, Weinberg K. Prevention of graft-versus-host disease by anti-IL-7Rα antibody. Blood. 2007;110(8): 2803-10.
Chung B, Dudl E, Toyama A, Barsky L, Weinberg K. Importance of IL-7 in the development of experimental graft-versus-host disease. Biol. Blood Marrow Transplant. 2008;14(1):16-27
Ren YX, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, Triche TJ, Shimada H, Anderson MJ. Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with second mutations. Cancer Res. 2008;68(16):6587-6597.
Huang g, Pshmforoush M, Chung B, Saxon LA. The role of cardiac electrophysiology in myocardial regenerative stem cell therapy. J Cardiovasc Transl Res. 2011;4(1):61-65.
Chung B, Min D, Krampf MR, Joo WJ, Huang J, Yang Y et. al. Combined effects of IL-7 and SCF administration on lymphopoiesis after murine bone marrow transplantation. Biol Blood Marrow Transplant. 2011 Jan;17(1):48-60.
Chung B, Stuge TB, Murad J, Beilhack G, Johannsen A, Andersen E, Weber JS, Lee PP. Immune regulation of high avidity T-cells by low avidity T-cells via trogocytosis effects target cell cytotoxicity and anti-tumor activity. Cell Rep. 2014;8(3):871-82.
Chung B, Ge S, Zhu J, Parekh C, Blumberg G, Arumugam B, Yang O, and Crooks GM. Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells. 2014;32(9):2386-96.
Chung B, Esmaeili A, Murad JP, Andersen E et al. Human brain metastatic stroma attracts breast cancer cells via chemokines CXCL16 and CXCL12. npj Breast Cancer (2017) 3:6 ; doi:10.1038/s41523-017-0008.
Chung B, Reddy N, Chu C, Esmaeili A et al. The use of EGFR-CD3 bispecific antibody and antigen- specific high avidity CTL to target cancer associated fibroblasts and cancer cells within a melanoma organoid model system (manuscript in preparation).